Involvement of nuclear factor-kappa B on corticosterone-induced rat Leydig cell apoptosis
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چکیده
منابع مشابه
Involvement of nuclear factor-kappa B on corticosterone- induced rat Leydig cell apoptosis.
AIM To investigate the activation of nuclear factor-kappa B (NF-kappa B) and its function in glucocorticoid-induced Leydig cell apoptosis. METHODS The Leydig cells were isolated from male Sprague-Dawley rats (90 days of age) and were incubated with corticosterone (CORT, glucocorticoid in rat) for 6 h, 12 h and 24 h, respectively. The P65 subunit of NF-kappa B (NF-kappa B/P65) in nuclei and th...
متن کاملNFAT2 is implicated in corticosterone-induced rat Leydig cell apoptosis.
AIM To investigate the activation of the nuclear factor of activated T cells (NFAT) and its function in the corticosterone (CORT)-induced apoptosis of rat Leydig cells. METHODS NFAT in rat Leydig cells was detected by Western blotting and immunohistochemical staining. Cyclosporin A (CsA) was used to evaluate potential involvement of NFAT in the CORT-induced apoptosis of Leydig cells. Intracel...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2006
ISSN: 1008-682X,1745-7262
DOI: 10.1111/j.1745-7262.2006.00212.x